Quick answer:
Rejuran Healer is a Korean skin booster made of polynucleotides (PN), DNA fragments purified from salmon, injected into the skin to support repair, hydration and texture. Clinics in Seomyeon often recommend a course of several sessions a few weeks apart. Improvements build gradually over weeks, and small injection bumps usually fade within a day or two.
What Polynucleotides Are
Polynucleotides are chains of nucleotides, the building blocks of DNA. In Rejuran, they are extracted and purified from salmon and processed to reduce the risk of immune reactions. Laboratory and clinical research suggests PN may support the skin's natural repair processes, encourage fibroblast activity and improve hydration, though the exact mechanisms are still being studied.
Rejuran is developed by a Korean company, PharmaResearch, and is approved in Korea by the Ministry of Food and Drug Safety (MFDS) as a medical device. It belongs to a wider category of PN and PDRN products. PDRN is a related, shorter-chain substance used in some regenerative treatments. Ask which product your clinic uses, as "salmon injections" can mean different products.
The Rejuran Product Family
- Rejuran Healer:
the original product for overall skin quality across the face.
- Rejuran i:
formulated for the thin skin around the eyes, used for fine lines and crepiness.
- Rejuran S:
designed for acne scars and depressed scars.
- Rejuran HB:
a version containing hyaluronic acid and lidocaine for comfort and hydration.
What Rejuran Healer May Help With
- Dull, tired-looking skin and uneven texture
- Fine lines and early loss of elasticity
- Dehydrated or sensitized skin, including after other procedures
- Enlarged-looking pores and mild redness in some people
- Skin thinning from frequent laser treatments, as part of a recovery plan
It is not a filler and does not lift sagging tissue or restore significant volume. Results tend to be subtle, and responses vary between individuals.
How Treatment Is Done
Rejuran is usually delivered with many small, shallow injections across the face, either by hand or using an injection device. Numbing cream is applied first because the injections can be uncomfortable, particularly over the forehead and around the nose. A typical full-face session takes around 20 to 40 minutes, plus numbing time.
Immediately after treatment, small raised bumps appear at each injection site, giving a temporary "embossed" texture. These usually flatten within a few hours to a day, but can last longer in some people.
Course and Results Timeline
Many doctors suggest a course of around three to four sessions spaced two to four weeks apart, followed by maintenance every few months. This varies with skin condition, age and goals.
- First week:
injection bumps fade; some people notice improved hydration.
- After two to three sessions:
texture and glow often look more even.
- After the full course:
results are generally easiest to judge, and may last several months.
Because collagen and repair processes take time, judging results after a single session can be misleading. Taking photos in the same lighting before each session is a simple way to track change, since gradual improvements are easy to overlook in the mirror. If you see no meaningful difference after a full course, discuss with your doctor whether a different approach suits your skin better.
Side Effects
- Small bumps, redness and swelling at injection points
- Pinpoint bruising
- Tenderness for a day or two
- Rarely, allergic reactions, infection or prolonged lumps
Who Should Not Have Rejuran
- People with fish or salmon allergy, or a known allergy to product ingredients
- Those who are pregnant or breastfeeding
- Anyone with active infection, cold sores or inflamed skin disease in the area
- People with autoimmune disease or bleeding disorders, unless their doctor approves
Aftercare
- Avoid makeup for the rest of the day, or as advised.
- Skip saunas, jjimjilbang, intense exercise and alcohol for at least the first day.
- Use gentle cleansers and moisturizer, and avoid exfoliating acids or retinoids for a few days.
- Apply sunscreen daily.
What Determines the Price
Rejuran is usually priced by the volume of product, commonly in 2 ml units, and by the version used. A full face may need more than one unit. Delivery method, numbing, combination with lasers and package discounts all influence the total. Ask for an itemized quote that states product name, volume and the number of sessions included.
Visiting Seomyeon for a Course
A multi-session course can be difficult for short-stay visitors. Some people do the first session in Busan and continue at home if the same product is available there, while long-stay residents and frequent visitors can complete the full course locally. If you come by KTX from Seoul for a weekend, keep in mind that injection bumps may be visible on the trip back, so a session on your first day is often more comfortable than one just before departure.
Frequently Asked Questions
Is Rejuran painful?
It is often described as one of the more uncomfortable skin boosters. Numbing cream and the HB version with lidocaine can help.
Can Rejuran be combined with laser treatments?
Yes, many doctors combine them, sometimes on the same day. Your doctor should decide the order and timing.
How is Rejuran different from hyaluronic acid boosters?
HA boosters mainly attract water and hydrate, while PN products like Rejuran are designed to support repair and regeneration.
Key Takeaways
- Rejuran Healer uses salmon-derived polynucleotides to support skin repair and quality.
- A course of several sessions is common, and results build gradually.
- Injection bumps usually fade within a day; downtime is short.
- People with fish allergy should avoid it; confirm the MFDS-approved product.
Medical disclaimer: This article is for general education only and does not replace a consultation with a licensed physician. Treatment suitability, results and risks vary by individual. In an emergency in Korea, call 119.
Last reviewed: October 2026.
